Inhibitory activity of several extract of Piper betle Leaf against S. aureus

A high number of infections from year to require infectious diseases get serious attention. The antimicrobial compound exploration must be continued anticipate the development diseases. purpose this study was find out in vitro activity n-hexane, ethyl acetate, and ethanol fractions Piper betle green leaves against S. aureus , profiles secondary metabolite compounds contained these three extracts. test carried by disk diffusion fraction at a concentration 6,25, 12,5, 18,75 µg/disk. Detection content done Thin Layer Chromatography method with stain-view reagents. highest found acetate significantly different n-hexane fractions. However, antibacterial all lower compared positive control amoxiclav 30µg/disk. phytochemical screening results metabolites each were shown that alkaloids, terpenoids, flavonoids, polyphenols, anthraquinone; while anthraquinone. Based on results, it is concluded leaf extract had activity; meanwhile, activities among others. Each proven have composition metabolites.